On the molecular mechanism of the AcrB RND-efflux pump
نویسندگان
چکیده
s 52
منابع مشابه
Binding site description of 2-substituted benzothiazoles as potential RND efflux pump inhibitors
The resistance-nodulation-cell division family (RND) efflux pumps exemplify a unique phenomenon with drug resistance in different gram negative bacterial strains as a single mechanism causing resistance against several different classes of antibiotics. In Escherichia coli AG102 and Acinetobacter baumannii SBMox2 strains the well characterized RND efflux pumps are AcrAB-TolC and the AdeABC respe...
متن کاملExpression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design
OBJECTIVES Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for the design of inhibitors. The aim of this study was to assess the viability of single transporters as a target for efflux inhibition using Salmonell...
متن کاملCoupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND-type proton/drug antiporter AcrB, the active component of the major efflux system AcrAB-TolC in ...
متن کاملPurification, crystallization and preliminary diffraction studies of AcrB, an inner-membrane multi-drug efflux protein.
Resistance of pathogens to antibiotics is often dependent on multi-drug export proteins that reside in the inner membrane of bacteria. This work describes the expression, purification, crystallization and preliminary crystallographic analysis of AcrB of Escherichia coli. Together with AcrA and TolC, AcrB forms a proton motive force dependent efflux pump of the resistance-nodulation-cell divisio...
متن کاملTheAcrABRNDe¥uxsystemfromthe livevaccine strain of Francisella tularensis isamultipledruge¥uxsystemthat isrequired for virulence inmice
The ability of bacterial pathogens to infect and cause disease is dependent upon their ability to resist antimicrobial components produced by their host, such as bile acids, fatty acids and other detergent-like molecules, and products of the innate immune system (e.g. cationic antimicrobial peptides). Bacterial resistance to the antimicrobial effects of such compounds is often mediated by activ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011